i
Report an error   
Advanced Search


A preclinical study on the analgesic and antipyretic properties of an oral dosage formula of herbal drug from ten medicinal plants in the Philippines.

Author

Jennylin B. Carreon,
Melfie E. Bungihan,
Gliceria A. Marzan,
Jherose H. Ampaya,
Aileen P. Baldonado,
Eden Leah B. Bumidang,
Rosanna R. dela Cruz

Related Institution

Center for Natural Sciences - Saint Mary's University

Department of Pharmacy - Saint Mary's University

Publication Information

Publication Type
Research Project
Date
July 1, 2015-March 11, 2016

Abstract

Ten medicinal plants were listed by the Philippine Department of Health as priority plants and were recognized as herbal plants due to their biological and pharmacological activities. Eight out of these were chosen namely akapulko, ampalaya, bawang, bayabas, lagundi, niyog-niyogan, pansit-pansitan, tsaang-gubat along with sampalok and okra seeds for the formulation of antipyretic and analgesic drugs. Toxicological and pharmacological assays were done on the individual extracts and on the three formulated Liqcap (500 mg/kg) containing different combinations of the individual extracts. Toxicological screening was done on triplicate set-up of Swiss mice (Mus musculus) based on Approximate Lethal Dose (ALD) by single-dose method and pharmacological observations were done on central nervous system (CNS) depression, CNS stimulation, eye observation, ear observation, and general observations and subjective tests. Results showed that after 24 and 48 hours, no CNS depression and stimulation were evident, eyes were normal, ears were normal, general observations and subjective tests were normal. Furthermore, results showed that the individual extracts and the three formulated Liqcap, were not toxic even up to 160 and 1, 500 mg/kg BW, respectively.  Based on the antipyretic assay, results show that Formulation 1 had the best antipyretic effect having a mean decrease of 4.3oC in the rectal temperature of the experimental animals after two hours of treatment. The results further reveal that there is a significant difference in the antipyretic property 30 minutes after the introduction of Formulation 1 to the feverish mice with sig. = 0.002 (α=0.05). Based on the analgesic assay, results present that in Formulation 1, the experimental animals can tolerate pain in the longest time having a mean average of 22.8 seconds. Thus, Formulation 1 containing 100 mg akapulko, 50 mg ampalaya, 140 mg bawang, 135 mg bayabas, 26 mg lagundi, 10 mg niyog-niyogan, 20 mg okra seeds, 5 mg pansit-pansitan, 12 mg sampalok and 2 mg tsaang-gubat can significantly reduce fever and can alleviate pain which is comparable to the over-the-counter synthetic drugs paracetamol and ibuprofen. 

References

1. Mradu, G , Banerjee, D , Arup, M . "Studies of anti-inflammatory, antipyretic and analgesic effects of aqueous extracts of traditional herbal drug on rodents" International Research Journal of Pharmacy 4(3): 113 – 120,
2. Guevara, Beatrice Q. A guidebook to plant screening: phytochemical and biological .. Manila: Research Center for the Natural Sciences, University of Santo Tomas. , 2004.
3. Abebe, W . "Herbal Medication: potential for adverse interactions with analgesic drugs" Journal of Clinical Pharmacy and Therapeutics 27, 391 – 401,
4. Banerjee, S , Mitra, A . "Changing landscape of herbal medicine: technology attributing renaissance" International Journal of Pharmacy and Pharmaceutical Sciences 4(1): 47-52,
5. Chandra, R , Kumarappan, C T, Kumar, J , Mandal, SC . "Antipyretic activity of JURU-01 - a polyherbal formulation" Global Journal of Pharmacology 4(1): 45-47,
6. Elumalai, A , Eswaraiah, M C, Sindhura, S , Rajendra, D , Manikanta, K , Rajkumar, C H. "Acute toxicity studies and antipyretic activity of a polyherbal formulation" International Journal of Biological & Pharmaceutical Research 3(1): 130 – 132,
7. Jayanthi, M K, Jyoti, M B. "Experimental animal studies on analgesic and anti-nociceptive activity of Allium sativum powder" IJRRMS 2(1): 1 – 6,
8. Khan, A , Rahman, M , Islam, S . "Antipyretic activity of Peperomia pellucida leaves in rabbit" Turk J Biol. 32, 37 – 41,
9. Ordoña, J F. "Traditional medicine in Republic of the Philippines" PITAHC , 81-87,
10. Oreagba, I A, Oshikoya, K A, Amachree, M . "Herbal medicine use among urban residents in Lagos, Nigeria" BMC Complementary and Alternative Medicine 11(117): 1 – 8,
11. Pal, S K, Shukla, Y . "Herbal medicine: current status and the future" Asian Pacific Journal of Cancer Prevention 4, 281 – 288,
12. Pitchaiah, G , Sharma, J , Satyavati, D . "Analgesic and anti-Inflammatory activity of methanolic extract of leaves of Quisqualis indica" Journal of Natural Remedies 12(2): 135 – 140,
13. Rivera, J O, Loya, A M, Ceballos, R . "Use of herbal medicines and implications for conventional drug therapy medical sciences" Alternative and Integrative Medicine 2(6): 1 – 6,
14. Soares-Bezerra, R J, Calheiros, A S, da Silva Ferreira, N C, da Silva Frutuoso, V , Alves, L A. "Natural products as a source for new anti-inflammatory and analgesic compounds through the inhibition of purinergic P2X receptors" Pharmaceuticals 6, 650 – 658,
15. Staines, S S. "Herbal medicines: adverse effects and drug-herb interactions" Journal of the Malta College of Pharmacy Practice 17, 38 – 42,
16. Tan, J G, Sia, I C. The Best 100 Philippine Medicinal Plants Quezon City: Health Futures Foundation, Inc, 2014.
17. Tilburt, J C, Kaptchuk, T J. "Herbal medicine research and global health: An ethical analysis" BullBulletin of the World Health OrganizationBulletin of the World Health Organizationetin of the World Health Organization 86(8): 594 – 599,
18. Ullah, M , Showkat, M , Ahmed, N U, Islam, S , Absar, N . "Evalutaion of Momordica charantia L. fruit extract for analgesic and anti-inflammatory activities using in vivo assay" Research Journal of Medicinal Plant , 1-9,

Physical Location

LocationLocation CodeAvailable FormatAvailability
Saint Mary Abstract Print Format

 
Loading…
©2021 HERDIN PLUS. All rights reserved.